Short List - Benefits of Resveratrol

• potential skin cancer and breast cancer prevention
• may improve heart and prostate health
• indications of metabolism improvement and weight loss


These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Suggested Use: As a dietary supplement take one lozenge in the morning under the tongue and take one lozenge in the evening under the tongue. Keep lozenge under the tongue until it dissolves completely.

Storage: Keep in a cool dark location. Product may change if exposed to moisture.

Resveratrol 25 mg

5% trans-resveratrol, Isomalt DC Steraic Acid, Grap Flavor, Magnesium Stearate, Stevia and Silicon Dioxide

Resveratrol is often touted as an incredible anti-aging and heart supplement. Please check your physician to see if this supplement is right for you.

Vital Therapy Resveratrol with sublingual lozenges of trans-resveratrol makes this a premier formulation for healthy aging. Bioavailability is key here. Furthermore, sublingual forms may deliver 200 - 300 times more supplement into the bloodstream vs. other forms. Therefore the bio-available, sublingual efficacy of Vital Therapy's Resveratrol supplement stands to deliver more potential benefit than a less expensive and less effective alternatives.


Following are a list of research studies where the benefits of resveratrol ever increase from cardio protection to breast cancer prevention, from skin cancer prevention to weight loss.

Columbia Dermatology report
Could Resveratrol, an Ingredient in Red Wine, Prevent Skin Cancer?

As far back as 6,000 B.C., our ancestorsrealized that red grapes had at least onespecial property — namely, that theycould be fermented into delicious wines.Now, it appears that these grapes haveeven more to offer: a molecule called res-veratrol. Numerous medical studies sug-gest that resveratrol, which some plantsproduce to ward off fungal infections,may help combat heart disease, cancer, Alzheimer’s disease, and other illnesses.Researchers at Columbia’s De-partment of Dermatology are studyingthis molecule as a possible preventivetreatment for basal cell and squamouscell skin cancers.“We got interested in resveratrolbecause it is very effective at blockingDNA damage induced by ultraviolet-B(UVB) light, which is the most impor-tant risk factor for skin cancer,” explainslead investigator Arianna Kim, Ph.D.,the Herbert Irving Assistant Professor ofDermatology. “When UVB light hits skincells, it can damage the DNA. If there’senough damage over time, the cells canbecome cancerous. So, we wanted tofind out if resveratrol could prevent orreverse adverse effects resulting fromthose genetic changes.”Thus far, the results are promising.In one experiment, mice were given regu-lar doses of an oral solution of resveratroland chronically exposed to UVB light.“We saw a 70-percent reduction in non-melanoma skin tumors in the treated mice,compared to a control group that didn’tget any resveratrol,” Dr. Kim reports.

dermatology.columbia.edu/SkinTouchW010draft13FINAL.pdf


Science Daily obesity review
Lemurs Lose Weight With 'Life-Extending' Supplement Resveratrol
ScienceDaily (June 22, 2010) — The anti-obesity properties of resveratrol have been demonstrated for the first time in a primate.

http://www.sciencedaily.com/releases/2010/06/100621215946.htm


Harvard findings
Resveratrol is found in red wines and produced by a variety of plants when put under stress. It was first discovered to have an anti-aging properties by Sinclair, other HMS researchers, and their colleagues in 2003 and reported in Nature. The 2003 study showed that yeast treated with resveratrol lived 60 percent longer. Since 2003, resveratrol has been shown to extend the lifespan of worms and flies by nearly 30 percent, and fish by almost 60 percent. It has also been shown to protect against Huntington's disease in two different animal models (worms and mice).

"The "healthspan" benefits we saw in the obese mice treated with resveratrol, such as increased insulin sensitivity, decreased glucose levels, healthier heart and liver tissues, are positive clinical indicators and may mean we can stave off in humans age-related diseases such as type 2 diabetes, heart disease, and cancer, but only time and more research will tell," says Sinclair, who is also a co-founder of Sirtris, a company with an author on this paper and which is currently in a phase 1b trial in humans with diabetes using an enhanced, proprietary formulation of resveratrol. [Harvard has license and equity interests with Sirtris, which is not a public company.]"
http://web.med.harvard.edu/sites/RELEASES/html/11_1Sinclair.html


WebMD
Resveratrol May Prevent Breast Cancer - In Test Tube, Red Wine Supplement Blocks Estrogen Toxicity
Prolonged exposure to estrogen is a major risk factor for breast cancer. Most research has focused on the interactions between estrogen and estrogen receptors on breast cancer cells.

But when the body's system for processing estrogen gets out of balance, dangerous estrogen metabolites appear. These toxic compounds react with DNA in breast cells and jump-start the growth of tumors.

Now Eleanor G. Rogan, PhD, and colleagues at the University of Nebraska show that resveratrol decreases the processing of estrogen into these dangerous compounds. Perhaps more importantly, it also blocks interactions between estrogen metabolites and cellular DNA.

And that's not all. Rogan's team finds that resveratrol increases production of an enzyme that destroys dangerous estrogen metabolites.

"Resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer," Rogan says in a news release. "We believe that this could stop the whole progression that leads to breast cancer down the road."

http://www.webmd.com/breast-cancer/news/20080707/resveratrol-may-prevent-breast-cancer


University of Oregon
At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens (17).

http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/


University of Wisconsin findings
Based on these studies, we suggest that resveratrol could be developed as an agent for the management of prostate cancer.

http://www.ncbi.nlm.nih.gov/pubmed/16731767


University of Connecticut research
The results indicate that resveratrol preconditions the hearts through adenosine A(3) receptor signaling that triggers the phosphorylation of CREB through both Akt-dependent and -independent pathways, leading to cardioprotection.

http://www.ncbi.nlm.nih.gov/pubmed/15879002